Which of the following is true regarding the ATF?

The Bureau of Alcohol, Tobacco, Firearms and Explosives (ATF) is primarily responsible for the regulation of firearms and explosives. This includes enforcing laws related to the sale, distribution, and manufacturing of these items, as well as overseeing the illicit trafficking of firearms and the regulation of explosives for safety purposes. The ATF also plays a role in combating organized crime and enforcing regulations concerning alcoholic beverages and tobacco products.

The other options pertain to different federal agencies: transportation safety is generally regulated by the Department of Transportation, interstate commerce falls under the jurisdiction of the Commerce Department, and currency regulations are overseen by the Department of the Treasury, particularly through the Financial Crimes Enforcement Network (FinCEN). Thus, the specific focus of the ATF aligns exclusively with firearms and explosives, making it the correct answer in the context of this question.